Intermittent catheterization (IC) is the gold standard for managing neurogenic voiding dysfunction. Indeed, employing this method to drain the bladder in cases of high post-void residual due to detrusor underactivity (neurogenic and/or drug-induced), bladder neck obstruction or detrusor sphincter dyssynergia has significantly decreased the risk of kidney failure, improved urinary incontinence, independence, and QoL. However, the occurrence of adverse events and the inability to perform IC are considered the main drawbacks. Commonly, IC regimen is associated with the use of antimuscarinics in patients having neurogenic detrusor overactivity (NDO). Intradetrusor botulinum toxin A (BoNT-A) is recommended when antimuscarinics are not sufficient to inhibit detrusor pressures and/or resolve urinary incontinence secondary to NDO. Urinary tract infection (UTI) and urinary retention are the major complications related to BoNT-A. When BoNT-A fails or patients desire a definitive solution, bladder augmentation (BA) should be considered. In neurogenic stress urinary incontinence (N-SUI), artificial sphincter is the best choice for men, whereas autologous sling is preferable for women. Both treatments may also be performed during bladder augmentation to subjects having neurogenic mixed urinary incontinence. Augmented cystoplasty is indicated in patients with NDO or reduced bladder compliance who fail with any other less invasive options. Additionally, in those presenting difficulties or inability to perform IC, a concomitant continent urinary diversion should be considered in conjunction with AC. The Brindley procedure (sacral deafferentation + sacral anterior root stimulation) may recover the ability to urinate and abolish the autonomic dysreflexia phenomenon in complete suprasacral spinal cord injury (SCI) patients. Some selected patients may need as salvage treatment a continent / incontinent urinary diversion with / without cystectomy.