This chapter explores the experience of loneliness as a given imaginative expression in religious or devotional poetry written in English during the seventeenth century. After an introductory consideration of the implications of isolation in the early modern period, there follows a series of questions: what do the religious poems of the seventeenth century reveal as the causes of spiritual loneliness, what are its symptoms, what metaphors are used to express it, and how do the poets suggest that it might be cured? The chapter goes on to examine some of the key contextual factors, including gender and genre, affecting the devotional poets’ approaches to isolation, and proposes two models—one early modern, one twentieth-century—to further our understanding of the phenomenon. The poets whose work is drawn upon represent the full range of denominational perspectives from Roman Catholic to Quaker, and a chronological span from 1610 to 1702. Framing the central discussion is George Herbert’s poem “Deniall” (1633), which exemplifies the prime cause of spiritual loneliness—the perceived absence of God—and enacts the curing of it through the writing of verse itself, a vital turn to prayer, and restored ‘ryming’ with God in the final stanza.