Nowadays, biomedical devices with integrated microelectronics are incorporated into modern healthcare systems. Advances in CMOS fabrication processes are further miniaturising these devices. These devices will be integrated on Implantable neural probes [1], pacemakers [1, 2]and many more. Thus, enhancing the quality of day-to-day healthcare. Such devices can be divided into several building blocks, see Fig. 8.1, such as sensors [3, 4], ADC [5], MEM devices [6], memory [7] and so on. These components are implemented to serve the purpose of recording, stimulation, and communication. Each of these not only has different functionalities also require different operating voltages and load currents powered by a battery or energy harvester through DC-DC converters. These converters are based on the charge pump designs. In search of reliable and efficient charge pump converter quality can be examined by performance and reliability, depicted in Fig. 8.2. Performance of the converter is defined by the power efficiency and voltage conversion ratio. On the other hand, reliability is defined upon converter’s ability to handle variation in output side (Load Regulation) and input side (Line Regulation).