This chapter provides a comprehensive overview of energy harvesting solutions for self-powering cardiovascular implantable medical devices. It explores different types of energy harvesters, including Triboelectric Nanogenerators (TENG), Piezoelectric Nanogenerators (PENG), Thermoelectric Generators (TEG), and Biofuel cells, along with novel materials, fabrication strategies, challenges, design aspects, and applications. The chapter delves into the unique operating principles of each energy harvester, elucidating how TENGs convert mechanical energy through the triboelectric effect, PENGs harness mechanical energy through piezoelectric materials, TEGs enable energy conversion from temperature gradients, and Biofuel cells utilize biological reactions for energy generation. It highlights the significance of materials selection, including flexible polymers, nanomaterials, and hybrid composites, to enhance device performance and biocompatibility. Fabrication strategies such as 3D printing, thin-film deposition, and microfabrication are explored in depth, emphasizing their role in producing complex and miniaturized energy harvesting devices. The chapter addresses challenges, including power optimization, miniaturization, reliability, and long-term stability. It also discusses design considerations like power management circuits and integration with existing medical devices to ensure efficient energy conversion and seamless implant integration. The applications of energy harvesting solutions in cardiovascular implants are highlighted, encompassing pacemakers, defibrillators, biosensors, and monitoring devices. The chapter emphasizes the potential for self-powered implants to reduce battery replacement surgeries, enhancing patient convenience and reducing healthcare costs.