The discovery and investigation of Neolithic habitations established in marginal zones of West MacedoniaMacedonia lakes[aut]Lake and marshes[aut]Marsh constituted an exceptional occasion for Greek prehistoric archaeology. The distinctive site-formation processes and the uniqueness of the preserved organic materials posed unprecedented practical, methodological, and interpretive challenges, offering at the same time new potentials for the study of the communities’ diachronic development. The present paper summarises the research results derived from the Rescue Excavations Project in the Four Lakes RegionFour Lakes (district, region) (AmindeonAmindeon Basin) and the latest data from the ongoing study by the Aristotle University of Thessaloniki (AUTH) of the DispilioDispilio lake[aut]Lake settlement[aut]Settlement in the framework of the ERC-funded EXPLO[aut] (EXPLO) project. The aim is to codify and evaluate the available information about the chronology[aut]Chronology of the habitations, their location in specific environmental settings, and the evidence regarding the construction and organisation of their built space. Subsequently, these characteristics are juxtaposed with documented parallels from the neighbouring areas to contextualise the specific attributes of the wetlands into the regional Neolithic. This comparative approach allows us to consider to what degree the wetland habitations constitute a unique phenomenon, or they are simply one of the diverse manifestations of the Western MacedoniaMacedonia Neolithic developed for specific—so far not detectable—reasons.