This chapter explores the ethical concerns of using artificial intelligence (AI) in technologies designed to support disabled people. While AI offers unprecedented opportunities to enhance independence, accessibility, and quality of life, its rapid development has raised numerous ethical concerns, especially regarding inclusivity, privacy, and autonomy. Through examining assistive technologies—from AI-driven prosthetics to screen readers and route-planning tools—this chapter investigates both the benefits and potential drawbacks AI brings to the lives of disabled people. It outlines the need for ethical leadership in establishing and implementing inclusive design principles, whereby the voices of disabled people are central to development. Ultimately, leaders across sectors must drive responsible, collaborative AI development to fulfil the technology’s potential as an empowering tool rather than one that inadvertently oppresses. A framework of best practices for ethical AI design is proposed, grounded in recent research, case studies, and the lived experiences of disabled individuals.