This entry delves into the intricate relationship between Islamic jurisprudence and contemporary medical definitions of brain death, exploring how varied interpretations affect end-of-life care within Muslim communities. It critically analyses the spectrum of Islamic views—from traditionalist interpretations that recognize only cardio-respiratory failure as death, to modern perspectives that accept neurological criteria as markers of death. Through detailed discussions, this entry evaluates how these theological positions influence practical decisions in healthcare settings, including the withdrawal of life support, organ donation, and the procedures for burial rites. A key feature of the entry is a table that categorizes different Islamic juridical views on brain death, highlighting their specific applications in clinical practice. This structured approach not only aids healthcare providers in understanding and navigating the religious and ethical complexities at the end of life but also serves as a guide for integrating these considerations into patient care, ensuring that treatment aligns with the diverse values and beliefs of Muslim patients and their families. The entry aims to foster a deeper understanding and enhance dialogue between medical professionals and Islamic scholars, promoting a more informed and compassionate approach to end-of-life care.