Medicinal plants have been used since time immemorial to heal mankind on all three tiers, namely, spiritual health, mental health, and physical health, through therapeutic recipes and nutraceuticals. Repurposed CRISPR-Cas-mediated genome editing has been successfully utilized for enhanced crop yield, stress tolerance, and production of various secondary metabolites including terpenoids, oleic acids, flavonoids, phenols, saponins, etc. The metabolic pathways are de-routed and en-routed via knock-out, knock-in, point-mutation, fine-tuning of gene-expression, and targeted mutagenesis as in Atropa, Cannabis, Chichorium, Dendrobium, Opium, Panax, Salvia, etc. A review of CRISPR-Cas-mediated genome editing through its variants provides limitless avenues for functional genomics, synthetic biology, and germplasm innovations in curative plants of commercial significance.