Plant extracts are a viable alternative to conventional medications for erectile dysfunction. They are used to increase sexual desire and performance. Numerous herbs are now being used to treat erectile dysfunction in modern medicine and folklore. They are frequently called aphrodisiacs. Aphrodisiac agents of plant origin are substances obtained from different plants that are thought to boost sexual pleasure, performance, or desire. All across the continents of the world, numerous cultures have employed plants and herbal treatments for their alleged aphrodisiac effects throughout history. It is important to note that scientific evidence supporting the effectiveness of many of these agents as aphrodisiacs can be limited and inconsistent. The major problem accompanying them is the unknown mechanism of action and the bioactive constituent responsible for their actions. This chapter reports the documented aphrodisiac agents of plant origin, across continents, and the bioactive components that are likely responsible for their sex-enhancing action in males.