While a large body of research supports the beneficial effects of mindfulness-based interventions, much less is known about the underlying mechanisms of action that explain their salutary effects. A more profound understanding of these mechanisms may further assist in enhancing the efficacy of these programs by accentuating features that are associated with therapeutic change. Mindful responding, or the nonjudgmental corrective act of returning attention back to on-going experience, is a fundamental component of all mindfulness-based interventions. The 4-item Daily Mindful Responding Scale (DMRS) was constructed to facilitate the investigation of mindful responding in daily life. Adapted for intensive repeated measurement methodologies, the DMRS can be used to examine the salutary effects of mindful responding in naturalistic settings. Initial findings support the reliability and validity of the DMRS for both between- and within-person analysis. However, future research is required to further validate its psychometric properties. The DMRS’s application for empirical research and clinical work are discussed.