Human-mammal interactions (HMI) are diverse and complex, encompassing cultural, historical, environmental, economic, and emotional dimensions. The goal of this chapter is to provide an overview of efforts toward understanding people’s perspectives of HMI in Latin America, outlining the most common terrestrial and aquatic mammalian species that have tended to interact with people across time and space. We used a Scope Review method to gather and summarize information. From 2000 to 2023, we observed an increase in publications related to HMI, with Brazil, Mexico, Chile, and Argentina leading the number of publications. We documented HMI involving at least 63 different species of mammals. While most terrestrial interactions involved large felids like jaguars and pumas, on water, interactions with humans mostly involved sea lions. Researchers have primarily focused on delineating people’s perceptions, covering how individuals view different species and their interactions with them as either positive or negative. While baseline research has provided valuable insights into attitudes, knowledge, and beliefs, there is a pressing need to document and monitor changes over time.