Diabetes is a chronic condition that poses a growing threat to both individual and public health due to its rapidly increasing global prevalence and the serious complications it can cause. Among the most severe consequences are diabetic foot ulcers (DFUs) and lower extremity amputations, which significantly contribute to increased morbidity, mortality, and healthcare costs. The development of DFUs is influenced by a range of risk factors and pathophysiological mechanisms, particularly in relation to glycemic control, vascular health, neuropathy, and infection. Following amputation, individuals often experience substantial losses in physical function, accompanied by significant psychosocial challenges and a marked reduction in quality of life. These consequences underscore the critical importance of well-structured home care processes to facilitate recovery and long-term adaptation. Effective strategies to address these needs include self-management support programs, digital health technologies, and family-centered care models, all of which can help prevent secondary complications while promoting physical, psychological, and social adjustment. Moreover, the integration of validated risk assessment tools, structured patient and caregiver education, and coordinated multidisciplinary care provides a comprehensive framework for delivering safe, effective, and sustainable home-based care that aligns with evidence-based best practices.