Disability protections have evolved over the years, shaping accessibility, employment inclusion, and social protections. Although there has been progress, societal attitudes and implementation challenges still hinder full inclusion for persons with disabilities. This entry examines disability protection laws/acts across continents, focusing on their impact, limitations, and opportunities for improvement across different regions. Whereas laws/acts establish the framework, regulations provide details on enforcement. The aim is to illuminate how these laws/acts converge on a core principle despite cultural and legal differences, to make sure that people living with disabilities are supported, empowered, and not disadvantaged by societal structures. Achieving full disability requires more than legal protection. It demands systemic changes in workplace policies, infrastructure, education access, and social awareness to encourage societal acceptance. Addressing enforcement gaps, ensuring proper accommodation, and fostering global cooperation can lead to more equitable and accessible societies for persons with disabilities. Strengthening advocacy efforts and refining legal frameworks can help bridge disparities. These factors can support meaningful progress toward universal disability rights and protections. The Disability protections embodied in laws and regulations in the United States of America, European Union, China, Australia, Nigeria, and the UN Convention on the Rights of Persons with Disabilities will be explored. Challenges in equitable enforcement, accessibility, and employment inclusion are highlighted, and opportunities for global collaboration, policy innovation, and stronger institutional support are discussed. Given translation challenges, access to certain data is limited, highlighting research and comparative challenges in global disability studies.