Quality of life (QoL) is a complex and multidimensional concept that reflects an individual’s overall sense of well-being across several domains, such as physical health, psychological state, social relationships, and environmental conditions. It is shaped by how individuals perceive their place within their cultural and societal contexts, considering their personal aspirations, expectations, and the values they hold. QoL is a universal concept that applies to everyone, regardless of disability status, background, or circumstances. In recent decades, there has been growing societal and scientific attention to the QoL of individuals with disabilities. This shift in focus has been driven by the transition from the medical model of disability, which emphasizes diagnosis and treatment, to the social model, which highlights inclusion, participation, and the overall well-being of people with disabilities within society. QoL of people with disabilities is increasingly becoming a central focus for intervention strategies and an important metric for evaluating the effectiveness of various support and rehabilitation programs. Many factors can impact QoL such as age, gender, education, health status, and employment status. In this chapter, we will explore the concept of QoL as a universal framework for understanding well-being in people with disabilities.