People with disabilities face persistent social, economic, and health inequities that limit their access to essential resources, including health care. Recognizing the barriers and challenges faced by this population needs to transcend the individualized view of these variables. This is especially true because general determinants overlap at multiple levels, from the proximal, such as age and gender, to the more distal levels, creating systemic barriers, such as inaccessible infrastructure, discrimination, and socioeconomic marginalization. The concept of intersectionality helps to illuminate how these overlapping disadvantages interact, exacerbating vulnerabilities in daily life. During the initial waves of the COVID-19 pandemic, preexisting inequities intensified, disproportionately affecting people with disabilities. Social distancing measures disrupted essential support systems, reduced access to health services, and increased social isolation, and people with the greatest need for support experienced increased exposure to the virus. Many individuals with disabilities experienced worsening mental and physical health due to reduced medical care, lack of support services, and economic instability. Furthermore, the shift to digital healthcare platforms often failed to accommodate their needs, further marginalizing this population. These compounded challenges have led to significant health consequences, including higher rates of morbidity and mortality among people with disabilities during the pandemic. The intersection of structural barriers, pandemic-related disruptions, and pre-existing vulnerabilities is essential to understanding the impact of COVID-19 on this population. A comprehensive response must incorporate an intersectional perspective to effectively address these disparities. Structural changes should focus on improving health-care accessibility, strengthening community support systems, ensuring economic security, and promoting inclusive education and employment opportunities. Furthermore, the active participation of people with disabilities in policy development and governance is crucial to advancing equity and mitigating the long-term health consequences of intersecting social injustices.