The COVID-19 pandemic has precipitated a global health crisis extending far beyond acute infection, giving rise to a chronic, multisystemic disease state known as postacute sequelae of SARS-CoV-2 (PASC), or Long COVID. Affecting an estimated 10–20% of survivors, this condition has caused significant medical, social, and economic consequences. This entry provides a comprehensive analysis of Long COVID-associated disabilities, examining some primary clinical domains: physical, neurological, psychiatric, respiratory, and cardiovascular disabilities. The widespread functional impairment across these domains creates an immense economic burden from lost workforce participation and increased healthcare costs, underscoring the urgent need for a systemic response. This entry advocates for integrated, multidisciplinary PASC clinics, widespread primary care education, and robust public policies that include workplace accommodations and stronger social support systems.