Bipolar disorder (BD) is a chronic psychiatric condition characterized by mood episodes ranging from mania to depression, with significant implications for occupational functioning. Disability in BD is often underestimated despite its profound impact on work performance, social integration, and economic stability. This entry explores the relationship between bipolar disorder and occupational functioning, examining the multifaceted nature of work-related disability in BD, including cognitive impairments, stigma, and systemic barriers. Additionally, it highlights therapeutic approaches such as vocational rehabilitation, workplace accommodations, and psychotherapeutic interventions aimed at improving employment outcomes. By addressing these challenges, this entry underscores the importance of integrative strategies to enhance occupational functioning and reduce the burden of disability in people with BD.