Cancer-related disabilities are the result of the disease and its treatment, and they present long-term morbidity, significantly diminishing quality of life among survivors. Examples of such disabilities include a variety of physical, cognitive, and psychological impairments that strikingly limit a person’s activities daily and full participation in society. Pathophysiological mechanisms underlying these impairments include direct tumor effects and treatment-related complications from surgery, radiation, and chemotherapy. Apart from the physical effects of poor health, the outcomes are multifaceted: they have psychological, social, and economic consequences—reinforcing their possible effects on independent living and social integration. A multidisciplinary approach toward rehabilitation is therefore required, making use of innovative treatments that take into consideration the physical and psychological features of disability. Early intervention will then prevent progression of impairments; survivorship care with comprehensive follow-up will help in the management of long-term consequences. It is necessary for research and clinical practice to look to strategies aimed at reducing the incidence and severity of disabilities from cancer. It is, therefore, in a better position to enhance the quality of life of cancer survivors by focusing on holistic care and rehabilitation processes that might restore them to normal living and independence.