The outcomes of cardiovascular disease (CVD) are crucial for monitoring both the condition and its management. Numerous studies provide snapshots of clinical, humanistic, and economic outcomes of CVD. There are only limited studies on disability caused by CVD. This chapter discusses CVD-related disability, the impact of cardiovascular disease on functional abilities, factors explaining the association between cardiovascular disease and disability, assessment methods for disability in CVD patients, the effectiveness of interventions to reduce disability, potential management strategies, and their impact on socioeconomic status and quality of life. The World Health Organization (WHO) has reported that one in six people experience significant disability due to the increase in elderly population and increase in the noncommunicable diseases. CVD significantly affects physical, cognitive, and psychosocial functioning. Although cardiovascular disease can cause disability, the relationship is found to be bidirectional. There are currently no definitive scales available to measure disability in CVD patients, likely due to the variations in disability caused by the disease. This chapter concludes that a comprehensive multidisciplinary approach is needed to address risk factors, promote early detection and prevention, provide thorough medical management, and support individuals with CVD-related disabilities.