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Metabolic Syndrome (MetS) encompasses a constellation of independent risk factors that collectively elevate the likelihood of developing cardiovascular diseases (CVD). Diagnosis of MetS is confirmed when a patient presents three or more of the five established risk factors. Unhealthy lifestyle habits, such as alcohol consumption, smoking, sedentary lifestyle and inadequate diet, increase the risk of developing MetS. Consequently, both MetS and environmental factors can modulate epigenetic mechanisms, which are involved in the regulation of gene expression. Among these mechanisms, microRNAs (miRNAs) play a crucial role in gene expression modulation and are linked to both physiological and pathological conditions. Different patterns of microRNA expression have been identified in diseases, indicating that there is a change in the miRNA expression profile inherent to the pathology. Changes in microRNA expression are associated with the regulation of signaling pathways related to the pathophysiology of MetS. This chapter discusses the pathophysiological and epigenetic processes associated with the development of MetS, emphasizing the role of microRNA in metabolic regulation.

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Epigenetics and Metabolic Syndrome: Role of microRNAs in Pathophysiology of Cardiometabolic Diseases

  • 动态工具书词条

  • 发表日期：

    2025年

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  • Helen Cristina Vidal,
  • Natália Ellen Delmicon,
  • Marcelo Macedo Rogero

摘要

Metabolic Syndrome (MetS) encompasses a constellation of independent risk factors that collectively elevate the likelihood of developing cardiovascular diseases (CVD). Diagnosis of MetS is confirmed when a patient presents three or more of the five established risk factors. Unhealthy lifestyle habits, such as alcohol consumption, smoking, sedentary lifestyle and inadequate diet, increase the risk of developing MetS. Consequently, both MetS and environmental factors can modulate epigenetic mechanisms, which are involved in the regulation of gene expression. Among these mechanisms, microRNAs (miRNAs) play a crucial role in gene expression modulation and are linked to both physiological and pathological conditions. Different patterns of microRNA expression have been identified in diseases, indicating that there is a change in the miRNA expression profile inherent to the pathology. Changes in microRNA expression are associated with the regulation of signaling pathways related to the pathophysiology of MetS. This chapter discusses the pathophysiological and epigenetic processes associated with the development of MetS, emphasizing the role of microRNA in metabolic regulation.