The prevalence of cardiometabolic diseases has continued to increase globally, despite advances in medical care. Dietary strategies like the Portfolio Diet are widely recommended to reduce disease risk. The Portfolio Diet emphasizes cholesterol-lowering foods, including nuts and seeds, plant protein sources (soy and dietary pulses), viscous fiber sources, plant sterols (from fortified foods or supplements), and plant-derived monounsaturated fatty acids (MUFA) sources. Clinical trials have shown that this diet reduces several established cardiometabolic risk factors, and cohort studies associate it with a lower risk of type 2 diabetes (T2D) and cardiovascular disease (CVD). Supported by plausible biological mechanisms and aligning with many principles of other healthy dietary patterns, the Portfolio Diet is a well-researched option for disease prevention and management. Despite its inclusion in guidelines, barriers to wider adoption exist, emphasizing the need for tools to support uptake. Translation tools like the PortfolioDiet.app can facilitate guideline-based diet adherence and support sustainable dietary changes that promote cardiometabolic health.