In 1949, Van Alyea described the sphenoid sinus as “…the most neglected of all nasal sinuses.” [1] He also agreed with Proetz who compared the sphenoid sinus to a man whose name begins with Z, because “They are always at the bottom of the list…” [2] During the last 25 years, we have seen a growing interest in the sphenoid sinus and its diseases. With the introduction of advanced and sophisticated surgical optics and instrumentation, followed by the introduction of novel surgical techniques (endoscopic and nonendoscopic), most rhinologic surgeons are now comfortable with approaching the sphenoid sinus surgically [3–8]. The sphenoid sinus has now reclaimed its position in the “center of the head”.