Richard Matheson repositioned the vampire as a collective undead affected by a germ that eludes human knowledge in his novel I Am Legend (1954). After him, and inspired by his work, George A. Romero set the basis for the contemporary apocalyptic zombies in Night of the Living Dead (1968). Decades prior to that, H. P. Lovecraft had published a couple of stories that deal with the reanimation of dead bodies, not by the work of natural degeneration or supernatural agents but by the inappropriate use of medical knowledge. At a time when zombies did not stand for the contemporary fear of epidemic contagion, in the 1920s, Lovecraft created the protagonists Herbert West, from Herbert West: Reanimator (1922), who is obsessed with restoring life to dead bodies—even dismembered parts of them—and Dr. Muñoz, from Cool Air (1928), who remains alive 18 years after the organic death of his body takes place. Both cases illustrate fears of the possibility that scientific advances may bring movement and even consciousness to a dead body with hideous consequences. This is witnessed by the narrators of both stories whose minds are filled with a repulsive horror as they remember the events they share with the reader. Thus, the purpose of this chapter is to analyze Lovecraft’s relived characters as zombies and explore how the author expresses through them fears about side effects of the advances of human science which, in his view, have not only provided the evidences necessary to suggest an infimal role for humanity in a cosmic context but also confirmed themselves as threats to our own existence if used in an ill manner.