Resident Evil tells a complicated tale of viral research, genetic engineering, industrial sabotage, and zombies—many, many zombies. This chapter intends to explore the franchise by using the multifarious viruses as the narrative backbone, taking it from being less about the primary characters caught up in the machinations of evil corporations and mad scientists and more into a tale of the genetics and the sciences involved. Where did t, G, and their variants come from? How and why did they escape, and what could we expect in the future from the franchise?