This chapter explores the interdisciplinary and ethnographic approaches employed in researching clinical communication within Chinese contexts, with a particular focus on Hong Kong. By integrating insights from applied linguistics, cultural studies, and healthcare communication, the chapter reviews key themes in Asian healthcare communication, including clinician-patient dynamics, family involvement in decision-making, and multilingual challenges. It emphasizes the sociocultural nuances that shape medical communication in East Asia, highlighting the integration of Western patient-centred models with Chinese cultural values. Through an interdisciplinary lens, the chapter underscores the importance of developing culturally appropriate communication frameworks to address the complex interplay of language, culture, and healthcare practices in Chinese societies. By presenting theoretical and practical insights, the chapter provides a foundation for subsequent discussions on culturally responsive healthcare communication strategies in multilingual and multicultural settings.