The intensifying impacts of climate change, including rising global temperatures, altered precipitation patterns, and an increased frequency of extreme weather events, have exacerbated abiotic stresses such as drought, salinity, heat, and flooding. These stresses impair photosynthesis, disrupt physiological processes, and reduce crop yields, posing significant challenges to global food security and agricultural sustainability. While traditional breeding and genetic engineering techniques have advanced the development of resilient crops, they are often limited by inefficiencies in speed and precision. Genome editing, particularly CRISPR/Cas9 system, offers a promising approach to overcoming climate change-induced challenges by enabling precise and efficient modifications of crop genomes to enhance resilience and adaptability to changing environmental conditions. This chapter explores the use of CRISPR-based genome editing for managing abiotic stresses in crop plants, highlighting numerous studies that demonstrate its potential for developing crops with improved stress tolerance traits, promote sustainable agricultural productivity, and ensure global food security amidst a changing climate.