Children are especially vulnerable to emergency or humanitarian contexts, particularly during periods of violence, starvation, natural disasters, forcible displacement, and other emergency circumstances. Recently, the world has experienced a lot of humanitarian emergencies last couple of years, both in the global south and north. As of the end of 2022, over 43.3 million children globally had been displaced due to war and violence. The proportion of children among the world’s refugees is much higher than their representation in the general population. In 2022, the percentage of children among the world’s refugees exceeded 41 percent, despite children being less than one-third of the worldwide population. In emergencies, children are most faced with protection concerns based on their ages, diversity, and social context. Efforts have focused on specifically addressing the needs of at-risk categories of children, including unaccompanied children, children involved in armed conflict, and children who have experienced gender-based violence. Child protection concerns have varied based on the geography, economic, and social conditions in the global south and north perspectives. The response strategies are also different from the context to the context. Humanitarian agencies and workers try to follow all the principles, standards, and law. In a humanitarian crisis, the child protection sub-sector is known as a CP Area of Responsibility (CPAoR) under the protection cluster worldwide for the coordination of response. This paper aims to investigate the present response mechanism in child protection in humanitarian situations, focusing on both the global south and north nations. It represented the reaction techniques and the personnel’s competencies and capabilities, which are interconnected with the response mechanism. This study also reflected the perspectives of child protection in a humanitarian setting in different regions.