This chapter examines women’s entrepreneurship globally, highlighting disparities between the Global North and South. Despite entrepreneurship’s role in economic growth, women’s participation lags behind men’s. It explores sociocultural, economic, educational, and institutional barriers, including gender stereotypes, limited access to finance, work-family conflicts, and inadequate policies. The chapter also analyzes strategies addressing these challenges, such as policy reforms, educational initiatives, corporate support, and advocacy campaigns, while identifying emerging opportunities for women entrepreneurs. Drawing on global case studies, it finds significant gender gaps persist, particularly in developing countries. The chapter concludes with a proposed research agenda emphasizing longitudinal and intersectional approaches and calls for collaboration among policymakers, educational institutions, and the private sector to foster a more inclusive entrepreneurial ecosystem.