The circular bioeconomy represents an emerging paradigm that integrates biological cycles, regenerative ecological processes, and circular economic logics into a coherent framework for long-term sustainability. Unlike classical circular economy approaches focused primarily on recycling and material efficiency, the circular bioeconomy places living systems, ecosystem regeneration, and biological productivity at its core. It is increasingly recognized as a necessary response to accelerating environmental crises, including climate change, biodiversity loss, soil degradation, and resource insecurity. This entry analyzes the circular bioeconomy as a complex socio-ecological transition, grounded in systems theory, innovation studies, ecological economics, and African epistemologies of interdependence. It highlights how regenerative resource systems—those capable of restoring soil fertility, enhancing biodiversity, and strengthening ecosystem resilience—can transform current extractive models of development. Drawing on global case studies, African Indigenous knowledge systems, and sustainability transitions theory, the entry demonstrates how circular bioeconomy pathways align with principles of adaptive governance, resilience, and inclusive development. It argues that the circular bioeconomy is not merely a technical shift but a civilizational transition requiring new norms, institutional architectures, and values. The entry concludes by outlining future scenarios for 2030–2050, with implications for policymakers, researchers, and sustainability practitioners.