Spinal vertebrae fractures may occur in athletes, often resulting from intense and repetitive physical activity. These injuries are frequently caused by acute trauma or repetitive micro-traumas and can lead to significant musculoskeletal issues, particularly in young athletes whose growth plates are still developing. This chapter highlights different injury mechanisms and patterns in both children and adults, with younger athletes more prone to avulsion fractures, while adults typically experience vertebral body fractures or disc ruptures. It provides insights into the epidemiology, biomechanics, diagnosis, treatment, and prevention of spinal fractures, emphasizing the lack of standardized guidelines for return to play after spinal fractures. Current treatment protocols focus on stabilizing fractures, managing pain, and restoring full function before allowing athletes to resume competition.