Treatment for emotional disorders in children and adolescents is increasingly being applied in a transdiagnostic manner to address the need for more broadly applicable yet mechanism-focused psychotherapy. The Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents (UP-C/A) are flexible, evidence-based treatment manuals that utilize evidence-based, largely cognitive and behavioral strategies to treat anxiety, mood, and other emotional disorders. In this chapter, we describe the rationale and empirical support for the use of the UP-C/A, provide a pragmatic overview of its contents, and briefly discuss application of core intervention components.