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Light-sheet microscopy allows rapid mesoscopic visualization of extended brain specimens. Combining this approach with tissue clearing and expansion is particularly fruitful. Here, we present a workflow for neuronal tissue clearing, expansion, and imaging that enables detailed mesoscopic mapping of neuronal connections with the ability to zoom in and out of selected neuronal circuits with virtual “super-resolution.”

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Light-Sheet Fluorescence Microscopy of Expanded Neuronal Tissue

  • 实验方案

  • 发表日期：

    2026年

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  • Juan Eduardo Rodriguez-Gatica,
  • Martin Karl Schwarz,
  • Ulrich Kubitscheck

摘要

Light-sheet microscopy allows rapid mesoscopic visualization of extended brain specimens. Combining this approach with tissue clearing and expansion is particularly fruitful. Here, we present a workflow for neuronal tissue clearing, expansion, and imaging that enables detailed mesoscopic mapping of neuronal connections with the ability to zoom in and out of selected neuronal circuits with virtual “super-resolution.”