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Despite the vital role T cells play in controlling T. cruzi infection and in the clinical progression of Chagas disease, their cellular metabolism remains poorly understood. SCENITH™ is a powerful technique in immunology that enables the evaluation of energetic metabolism at single-cell resolution. In this chapter, we will provide an overview of the application of this innovative assay to evaluate the metabolism of T lymphocytes from patients with different stages of chronic Chagas disease.

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Assessing the Metabolic Profile of CD4+ and CD8+ T Lymphocytes in Chronic Chagas Disease Patients Using SCENITH

  • 实验方案

  • 发表日期：

    2026年

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  • Karen M. Cruz,
  • Fátima Ferragut,
  • Felipe Flores-Santibañez,
  • Rafael J. Argüello,
  • Karina Andrea Gómez

摘要

Despite the vital role T cells play in controlling T. cruzi infection and in the clinical progression of Chagas disease, their cellular metabolism remains poorly understood. SCENITH™ is a powerful technique in immunology that enables the evaluation of energetic metabolism at single-cell resolution. In this chapter, we will provide an overview of the application of this innovative assay to evaluate the metabolism of T lymphocytes from patients with different stages of chronic Chagas disease.