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Group 3 medulloblastoma (MBGrp3), predominantly affecting young children, is often associated with MYC amplification and/or overexpression, frequent metastasis, and poor prognosis. To elucidate the mechanisms underlying phenomena that enhance the malignancy of such cancers, it is imperative to use mouse models that reflect the characteristics of human Group 3 tumors. In this chapter, we demonstrate highly aggressive MBGrp3 mouse models by transducing cerebellar progenitor cells with Myc and a dominant-negative mutant form of TP53.

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In Vivo Mouse Models of Myc-Driven Medulloblastoma

  • 实验方案

  • 发表日期：

    2025年

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  • Wanchen Wang,
  • Daisuke Kawauchi

摘要

Group 3 medulloblastoma (MBGrp3), predominantly affecting young children, is often associated with MYC amplification and/or overexpression, frequent metastasis, and poor prognosis. To elucidate the mechanisms underlying phenomena that enhance the malignancy of such cancers, it is imperative to use mouse models that reflect the characteristics of human Group 3 tumors. In this chapter, we demonstrate highly aggressive MBGrp3 mouse models by transducing cerebellar progenitor cells with Myc and a dominant-negative mutant form of TP53.