Optical genome mapping (OGM) is a robust method for identifying and characterizing chromothripsis. While conventional short-read sequencing techniques encounter challenges in detecting chromothripsis due to limitations in read length and difficulties in analyzing repetitive sequences, OGM leverages the visualization of long DNA molecules to overcome these obstacles. OGM involves a multi-step process, starting with the extraction of ultra-high molecular weight DNA, followed by fluorescent labeling and imaging of the stretched molecules in nanochannels. A specific computational pipeline analyzes the resulting data to detect and categorize structural variations and copy number variations, offering a comprehensive, high-resolution view of genetic alterations across the genome. Despite certain limitations, such as the requirement for specialized DNA extraction and the inability to detect specific types of variations, OGM stands out as a powerful tool for chromothripsis detection and characterization, complementing existing methods and providing valuable insights into genome structure and variations.