Scholarlink

Digital outcome measures utilizing digital devices and instruments are highly effective in capturing significant changes quantitatively in clinical trials of patients with Duchenne muscular dystrophy. A dystrophic model of beagle dogs, known as canine X-linked muscular dystrophy in Japan (CXMDJ), shows the symptoms of muscle weakness and has been evaluated for motor function using these digital outcome measures to assess therapeutic efficacy and monitor disease progression circumstantially. Here, we present accelerometry methods for analyzing gait function and infrared monitoring analysis for assessing spontaneous locomotor activity in CXMDJ dystrophic dogs. The multiple parameters derived from these methods can provide valuable phenotypic information in medium-to-large-sized experimental animals.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Digital Outcome Measures for Gait and Spontaneous Locomotor Activity in Dystrophic Dogs

  • 实验方案

  • 发表日期：

    2026年

查看全文
  • Mutsuki Kuraoka,
  • Karin Watanabe,
  • Takahiro Kawashima,
  • Yuko Nitahara-Kasahara,
  • Hisateru Tachimori,
  • Shin’ichi Takeda,
  • Katsura Minegishi,
  • Yoshitsugu Aoki

摘要

Digital outcome measures utilizing digital devices and instruments are highly effective in capturing significant changes quantitatively in clinical trials of patients with Duchenne muscular dystrophy. A dystrophic model of beagle dogs, known as canine X-linked muscular dystrophy in Japan (CXMDJ), shows the symptoms of muscle weakness and has been evaluated for motor function using these digital outcome measures to assess therapeutic efficacy and monitor disease progression circumstantially. Here, we present accelerometry methods for analyzing gait function and infrared monitoring analysis for assessing spontaneous locomotor activity in CXMDJ dystrophic dogs. The multiple parameters derived from these methods can provide valuable phenotypic information in medium-to-large-sized experimental animals.