Scholarlink

Advanced glycation end products (AGEs) are formed both exogenously in foods and endogenously through metabolic processes. Their key precursors, glyoxal (GO), methylglyoxal (MGO), and 3-deoxyglucosone (3-DG), are reactive dicarbonyl compounds. This study outlines the analytical procedures for quantifying GO, MGO, CML, CEL, and furosine using high-performance liquid chromatography (HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Sample preparation includes derivatization, extraction, and purification steps specific to each analyte. The described methods enable precise detection of AGEs and their precursors in complex matrices.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Analysis of Advanced Glycation End Products (AGEs)

  • 章节

  • 发表日期：

    2025年

查看全文
  • Mustafa Yaman,
  • Halime Uğur,
  • Esra Yıldırım Servi,
  • Ayşe Binnur Karataş

摘要

Advanced glycation end products (AGEs) are formed both exogenously in foods and endogenously through metabolic processes. Their key precursors, glyoxal (GO), methylglyoxal (MGO), and 3-deoxyglucosone (3-DG), are reactive dicarbonyl compounds. This study outlines the analytical procedures for quantifying GO, MGO, CML, CEL, and furosine using high-performance liquid chromatography (HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Sample preparation includes derivatization, extraction, and purification steps specific to each analyte. The described methods enable precise detection of AGEs and their precursors in complex matrices.