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Photolabile linkers are chemically very stable and can be cleaved under mild conditions without destructive reactions on target molecules. o-Nitrobenzyl-based linkers are widely used in solid phase synthesis. Recently, our group developed several o-nitrobenzylic-based photolabile resins retaining different modifications at reducing-end of glycans after photocleavage. Here, we described the synthesis of three different o-nitrobenzylic derivatives and the immobilization of linkers on commercial Merrifield resin. Subsequently, detailed procedures of loading determination and photocleavage are presented.

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Photolabile Linkers for Solid-Phase Synthesis of Oligosaccharides

  • 实验方案

  • 发表日期：

    2025年

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  • Yan-Ting Kuo,
  • Kim Le Mai Hoang,
  • Peter H. Seeberger

摘要

Photolabile linkers are chemically very stable and can be cleaved under mild conditions without destructive reactions on target molecules. o-Nitrobenzyl-based linkers are widely used in solid phase synthesis. Recently, our group developed several o-nitrobenzylic-based photolabile resins retaining different modifications at reducing-end of glycans after photocleavage. Here, we described the synthesis of three different o-nitrobenzylic derivatives and the immobilization of linkers on commercial Merrifield resin. Subsequently, detailed procedures of loading determination and photocleavage are presented.