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Amphiphilic glycopeptides and glycopolymers have been characterized as potential glycocalyx engineering probes to regulate growth factors mediated stem cell differentiation and neural plasticity. Here, we describe a rational and facile method to synthesize fluorescent tagged amphiphilic multivalent glycoprobes using solid-phase peptide synthesizer and copper-free click chemistry. As a prototype, we report the synthesis of fluorescently tagged penta-valent sulfated L-iduronic acid glycopeptide for cell surface engineering and imaging.

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Amphiphilic Glycoprobes for Cell Surface Engineering and Drug Delivery

  • 实验方案

  • 发表日期：

    2025年

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  • Saurabh Anand,
  • Preeti Ravindra Bhoge,
  • Raghavendra Kikkeri

摘要

Amphiphilic glycopeptides and glycopolymers have been characterized as potential glycocalyx engineering probes to regulate growth factors mediated stem cell differentiation and neural plasticity. Here, we describe a rational and facile method to synthesize fluorescent tagged amphiphilic multivalent glycoprobes using solid-phase peptide synthesizer and copper-free click chemistry. As a prototype, we report the synthesis of fluorescently tagged penta-valent sulfated L-iduronic acid glycopeptide for cell surface engineering and imaging.