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Matrix-assisted laser desorption/ionization–mass spectrometry imaging (MALDI-MSI) is widely recognized as a leading method for studying spatial omics. Spatial multiomics platforms are most effective when they integrate multimodal datasets to provide a comprehensive understanding of biological contexts. By combining approaches like metabolomics and lipidomics, the throughput of spatial analysis methods can be significantly enhanced. In this particular protocol, polyamine pathway-related metabolites and lipids from a mouse optic nerve are imaged using atmospheric pressure MALDI.

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Polyamine Metabolism in Optic Nerve: Spatial Metabolomics with AP/MALDI Mass Spectrometry Imaging

  • 实验方案

  • 发表日期：

    2025年

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  • Sean Meehan,
  • Caleigh O’Connor,
  • Eugene Moskovets,
  • Konstantin Novoselov,
  • Nivedita Bhattacharya,
  • Sanjoy K. Bhattacharya

摘要

Matrix-assisted laser desorption/ionization–mass spectrometry imaging (MALDI-MSI) is widely recognized as a leading method for studying spatial omics. Spatial multiomics platforms are most effective when they integrate multimodal datasets to provide a comprehensive understanding of biological contexts. By combining approaches like metabolomics and lipidomics, the throughput of spatial analysis methods can be significantly enhanced. In this particular protocol, polyamine pathway-related metabolites and lipids from a mouse optic nerve are imaged using atmospheric pressure MALDI.