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The formation of cardiac organoids brings a new 3D model of cardiac development. The organoid is also very helpful in screening drug efficiency or toxicity. Inspired by cardiac biology of development, a step-by-step protocol is described to generate cardiac chamber-like organoids from pluripotent stem cells. A few examples of functional tests and the use of these organoids for drug toxicity are reported.

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A Robust Protocol for Pluripotent Stem Cell Modeling of 3D Chamber-Like Cardiac Organoids

  • 实验方案

  • 发表日期：

    2025年

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  • Michel Pucéat

摘要

The formation of cardiac organoids brings a new 3D model of cardiac development. The organoid is also very helpful in screening drug efficiency or toxicity. Inspired by cardiac biology of development, a step-by-step protocol is described to generate cardiac chamber-like organoids from pluripotent stem cells. A few examples of functional tests and the use of these organoids for drug toxicity are reported.