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Spherical nucleic acids (SNAs) offer intriguing properties for cellular uptake and stability. A novel SNA-like structure known as the nucleic acid nanocapsule (NAN) combines the benefits of SNAs with the added properties of nucleic acid functionalization and drug cargo release. Herein, we will discuss various ways NANs can be adapted to allow for gene targeting via the delivery of nucleic acids, as well as the delivery of small molecule drugs for combination therapies.

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Enzymatically Ligated Nucleic Acid Nanocapsules for the Delivery of Therapeutic Nucleic Acids and Small Molecule Drugs

  • 实验方案

  • 发表日期：

    2025年

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  • Jenna N. Cannata,
  • Jessica L. Rouge

摘要

Spherical nucleic acids (SNAs) offer intriguing properties for cellular uptake and stability. A novel SNA-like structure known as the nucleic acid nanocapsule (NAN) combines the benefits of SNAs with the added properties of nucleic acid functionalization and drug cargo release. Herein, we will discuss various ways NANs can be adapted to allow for gene targeting via the delivery of nucleic acids, as well as the delivery of small molecule drugs for combination therapies.