Scholarlink

Mechanical forces play crucial roles in regulating cellular communications. It has been challenging to measure intercellular forces due to the lack of proper tools. We have recently developed lipid-modified DNA probes that can anchor on the cell membranes and detect intercellular tensions through targeting particular cell surface receptors of interest. Herein, we describe the methods to synthesize, characterize, and apply these DNA-based fluorescent probes for imaging and quantifying intercellular forces.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Method for Imaging and Quantifying Molecular Tensions at Cell–Cell Junctions Using DNA-Based Fluorescent Probes

  • 实验方案

  • 发表日期：

    2025年

查看全文
  • Priyanka Bhattacharyya,
  • Qian Tian,
  • Mingxu You

摘要

Mechanical forces play crucial roles in regulating cellular communications. It has been challenging to measure intercellular forces due to the lack of proper tools. We have recently developed lipid-modified DNA probes that can anchor on the cell membranes and detect intercellular tensions through targeting particular cell surface receptors of interest. Herein, we describe the methods to synthesize, characterize, and apply these DNA-based fluorescent probes for imaging and quantifying intercellular forces.