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In vivo peptide-phage display is a powerful, agnostic technique for identification of homing peptides and mapping of the vascular diversity. This chapter provides a practical guide for conducting in vivo T7 phage biopanning experiments and analyzing the data. It details experimental designs and protocols, emphasizing the use of high-throughput sequencing (HTS) technologies to enhance the efficiency of in vivo biopanning and the validation of tumor-targeting peptides.

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Identification of Organ- and Disease-Specific Homing Peptides Using In Vivo Peptide-Phage Display

  • 实验方案

  • 发表日期：

    2025年

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  • Kristina Põšnograjeva,
  • Karlis Pleiko,
  • Tambet Teesalu

摘要

In vivo peptide-phage display is a powerful, agnostic technique for identification of homing peptides and mapping of the vascular diversity. This chapter provides a practical guide for conducting in vivo T7 phage biopanning experiments and analyzing the data. It details experimental designs and protocols, emphasizing the use of high-throughput sequencing (HTS) technologies to enhance the efficiency of in vivo biopanning and the validation of tumor-targeting peptides.