Suicide is a serious and growing public health concern, and evidence-based suicide assessments and interventions are crucial to caring for and treating individuals experiencing suicidal thoughts and behavior. Interviewing this population is often seen as a complex arduous task. However, with appropriate training and knowledge, clinicians can begin to develop the confidence and expertise to work effectively with those at risk for suicide. This chapter reviews the numerous considerations that clinicians should keep in mind when conducting interviews with this population, including the use of structured versus semi-structured approaches, specific assessment tools, interview settings, safety considerations, and a comprehensive array of risk and protective factors. It outlines critical domains to assess during a clinical interview, such as suicidal thinking, planning, preparation, history of suicidal behavior, precipitating stressors, and co-occurring psychiatric disorders. The chapter advocates for clinicians to establish a usual and customary practice for working with suicidal individuals, emphasizing an empathic approach that considers cultural and racial identities and addresses potential barriers to disclosure and help-seeking behavior. Ultimately, this chapter serves as a guide for clinicians, stressing the integration of evidence-based tools and empathetic engagement to enhance the assessment and management of suicide risk.