Somatic Symptom and Related Disorders (SSRD) are a very heterogeneous group of mental health disorders. They include disorders characterized by persistent somatic symptoms with associated distress and disability (SSD, FNSD), by a cognitive preoccupation of having or gaining a somatic condition (IAD), by psychological factors that impact the onset and perpetuation of somatic symptoms (PFAOMC), or by induced somatic or mental symptoms (FD). Compared to many other mental disorders, it is important to consider that SSRD are phenomena in the intersection between medicine, psychology, and other healthcare disciplines. That makes the diagnostic process unique compared to other disorders, and, in addition to the application of common diagnostic tools in mental health (e.g., structured interviews, self-report, and observational tools), it is central to establish a strong collaborative relationship with the patient’s healthcare providers. If possible and if time is given, the diagnostician should also involve other informants (e.g., spouse, family members).