Hepatic encephalopathy (HE) is a potentially reversible metabolic syndrome resulting from liver dysfunction. Typically, diagnosis of HE relies on a combination of clinical findings, laboratory tests to assess liver function, and evaluation of portal-systemic circulation. However, in certain cases, these methods may not be good enough. Hence, additional auxiliary tools may be necessary for an accurate differential diagnosis. Neuroimaging has emerged as a powerful asset in this regard, enabling identification of prevalent features of HE such as manganese accumulation, brain edema, and brain atrophy. Moreover, neuroimaging helps exclusion of other neurological conditions with similar clinical signs to HE, thereby increasing diagnostic accuracy. Consequently, neuroimaging is gaining relevance in clinical practice for the differential diagnosis of HE and other multiple neurological conditions. In this chapter, we will outline diverse neuroimaging procedures suitable for identifying pathological features of HE, describing the protocols and specific features observable with each modality. Finally, we will explore some basic preprocessing techniques designed to enhance neuroimaging quality and increase their reliability and sensitivity to pathological alterations.