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Prenatal stress (PS) impacts early behavioral, neuroimmune, and cognitive development. Pregnant rat models have been very valuable in examining the mechanisms of such fetal programming. A pregnant sheep model of maternal stress offers the unique advantages of chronic in utero monitoring and manipulation. This chapter presents the techniques used to model single and multigenerational stress exposures and their pleiotropic effects on the offspring.

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Perinatal Psychoneuroimmunology of Prenatal Stress and Its Effects on Fetal and Postnatal Brain Development

  • 实验方案

  • 发表日期：

    2025年

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  • Martin G. Frasch,
  • Colin Wakefield,
  • Ben Janoschek,
  • Yael S. Frank,
  • Floyd Karp,
  • Nicholas Reyes,
  • Andre Desrochers,
  • Mary C. Wallingford,
  • Marta C. Antonelli,
  • Gerlinde A. S. Metz

摘要

Prenatal stress (PS) impacts early behavioral, neuroimmune, and cognitive development. Pregnant rat models have been very valuable in examining the mechanisms of such fetal programming. A pregnant sheep model of maternal stress offers the unique advantages of chronic in utero monitoring and manipulation. This chapter presents the techniques used to model single and multigenerational stress exposures and their pleiotropic effects on the offspring.