Drought stress has a significant impact on plant growth and productivity. Plants have evolved several adaption mechanisms to deal with drought stress. Plant microbiome engineering is a promising field to minimize drought stress and ensure food security. It has emerged as a novel and promising method for boosting crop drought resilience and promoting sustainable agriculture. Plants adopt a “cry for help” approach under drought stress to rebuild their microbiome, which not only lowers stress but also increases nutrient availability and overall plant health. However, to maximize the potential of the plant microbiome, it is important to understand the complex interactions that occur between bacteria and plants before and after water stress. High-throughput techniques have revealed chemical, biological, and molecular characteristics of the plant microbiome under severe drought as well as a roadmap for future efforts to increase drought stress resilience in economically useful crops. This chapter discusses the method to utilize rhizospheric bacteria to mitigate drought stress via host-mediated microbiome engineering (HMME).