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Preclinical studies of optic nerve injury models have led to significant insight into the mechanism underlying retinal ganglion cell neurodegeneration. During the process of ganglion cell injury, morphological changes can occur prior to gross structural changes and cell death. Similarly, following injury, functional changes can occur in the absence of substantive structural changes. These more subtle effects can often be detected using functional tools such as the electroretinogram. Moreover, the electroretinogram is a sensitive and complementary means to quantify treatment efficacy. Here, we describe in vivo electroretinography for assessing ganglion cell injury in rodent models.

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Full-Field Electroretinogram Responses in Rodent Models of Ganglion Cell Injury

  • 实验方案

  • 发表日期：

    2025年

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  • Da Zhao,
  • Pei Ying Lee,
  • Vickie H. Y. Wong,
  • Anh Hoang,
  • Katie K. N. Tran,
  • Anna K. Van Koeverden,
  • Brianna C. Afiat,
  • Christine T. O. Nguyen,
  • Bang V. Bui

摘要

Preclinical studies of optic nerve injury models have led to significant insight into the mechanism underlying retinal ganglion cell neurodegeneration. During the process of ganglion cell injury, morphological changes can occur prior to gross structural changes and cell death. Similarly, following injury, functional changes can occur in the absence of substantive structural changes. These more subtle effects can often be detected using functional tools such as the electroretinogram. Moreover, the electroretinogram is a sensitive and complementary means to quantify treatment efficacy. Here, we describe in vivo electroretinography for assessing ganglion cell injury in rodent models.